United States securities and exchange commission logo August 18, 2021 Peter K. Miller Chief Executive Officer OptiNose, Inc. 1020 Stony Hill Road, Suite 300 Yardley, Pennsylvania 19067 Re: OptiNose, Inc. Registration Statement on Form S-3 Filed August 11, 2021 File No. 333-258707 Dear Mr. Miller: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Gary Guttenberg at (202) 551-6477 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Stephen M. Nicolai